This sounds like a scenario where zeroMQ would be a good fit. It's a messaging framework that's similar to using TCP or Unix sockets, but it's much more robust (http://zguide.zeromq.org/py:all)

There's a library that uses zeroMQ to provide a RPC framework that works pretty well. It's called zeroRPC (http://www.zerorpc.io/). Here's the hello world.

Python "Hello x" server:

import zerorpc

class HelloRPC(object):
    '''pass the method a name, it replies "Hello name!"'''
    def hello(self, name):
        return "Hello, {0}!".format(name)

def main():
    s = zerorpc.Server(HelloRPC())
    s.bind("tcp://*:4242")
    s.run()

if __name__ == "__main__" : main()

And the node.js client:

var zerorpc = require("zerorpc");

var client = new zerorpc.Client();
client.connect("tcp://127.0.0.1:4242");
//calls the method on the python object
client.invoke("hello", "World", function(error, reply, streaming) {
    if(error){
        console.log("ERROR: ", error);
    }
    console.log(reply);
});

Or vice-versa, node.js server:

var zerorpc = require("zerorpc");

var server = new zerorpc.Server({
    hello: function(name, reply) {
        reply(null, "Hello, " + name, false);
    }
});

server.bind("tcp://0.0.0.0:4242");

And the python client

import zerorpc, sys

c = zerorpc.Client()
c.connect("tcp://127.0.0.1:4242")
name = sys.argv[1] if len(sys.argv) > 1 else "dude"
print c.hello(name)

This sounds like a scenario where zeroMQ would be a good fit. It's a messaging framework that's similar to using TCP or Unix sockets, but it's much more robust (http://zguide.zeromq.org/py:all)

There's a library that uses zeroMQ to provide a RPC framework that works pretty well. It's called zeroRPC (http://www.zerorpc.io/). Here's the hello world.

Python "Hello x" server:

import zerorpc

class HelloRPC(object):
    '''pass the method a name, it replies "Hello name!"'''
    def hello(self, name):
        return "Hello, {0}!".format(name)

def main():
    s = zerorpc.Server(HelloRPC())
    s.bind("tcp://*:4242")
    s.run()

if __name__ == "__main__" : main()

And the node.js client:

var zerorpc = require("zerorpc");

var client = new zerorpc.Client();
client.connect("tcp://127.0.0.1:4242");
//calls the method on the python object
client.invoke("hello", "World", function(error, reply, streaming) {
    if(error){
        console.log("ERROR: ", error);
    }
    console.log(reply);
});

Or vice-versa, node.js server:

var zerorpc = require("zerorpc");

var server = new zerorpc.Server({
    hello: function(name, reply) {
        reply(null, "Hello, " + name, false);
    }
});

server.bind("tcp://0.0.0.0:4242");

And the python client

import zerorpc, sys

c = zerorpc.Client()
c.connect("tcp://127.0.0.1:4242")
name = sys.argv[1] if len(sys.argv) > 1 else "dude"
print c.hello(name)

Update 2019

There are several ways to achieve this and here is the list in increasing order of complexity

1. Python Shell, you will write streams to the python console and it will write back to you
2. Redis Pub Sub, you can have a channel listening in Python while your node js publisher pushes data
3. Websocket connection where Node acts as the client and Python acts as the server or vice-versa
4. API connection with Express/Flask/Tornado etc working separately with an API endpoint exposed for the other to query

Approach 1 Python Shell Simplest approach

source.js file

const ps = require('python-shell')
// very important to add -u option since our python script runs infinitely
var options = {
    pythonPath: '/Users/zup/.local/share/virtualenvs/python_shell_test-TJN5lQez/bin/python',
    pythonOptions: ['-u'], // get print results in real-time
    // make sure you use an absolute path for scriptPath
    scriptPath: "./subscriber/",
    // args: ['value1', 'value2', 'value3'],
    mode: 'json'
};

const shell = new ps.PythonShell("destination.py", options);

function generateArray() {
    const list = []
    for (let i = 0; i < 1000; i++) {
        list.push(Math.random() * 1000)
    }
    return list
}

setInterval(() => {
    shell.send(generateArray())
}, 1000);

shell.on("message", message => {
    console.log(message);
})

destination.py file

import datetime
import sys
import time
import numpy
import talib
import timeit
import json
import logging
logging.basicConfig(format='%(asctime)s : %(levelname)s : %(message)s', level=logging.INFO)

size = 1000
p = 100
o = numpy.random.random(size)
h = numpy.random.random(size)
l = numpy.random.random(size)
c = numpy.random.random(size)
v = numpy.random.random(size)

def get_indicators(values):
    # Return the RSI of the values sent from node.js
    numpy_values = numpy.array(values, dtype=numpy.double) 
    return talib.func.RSI(numpy_values, 14)

for line in sys.stdin:
    l = json.loads(line)
    print(get_indicators(l))
    # Without this step the output may not be immediately available in node
    sys.stdout.flush()