You can now use RPC libraries that support Python and Javascript such as zerorpc

From their front page:

Node.js Client

var zerorpc = require("zerorpc");

var client = new zerorpc.Client();
client.connect("tcp://127.0.0.1:4242");

client.invoke("hello", "RPC", function(error, res, more) {
    console.log(res);
});

Python Server

import zerorpc

class HelloRPC(object):
    def hello(self, name):
        return "Hello, %s" % name

s = zerorpc.Server(HelloRPC())
s.bind("tcp://0.0.0.0:4242")
s.run()

Most of previous answers call the success of the promise in the on("data"), it is not the proper way to do it because if you receive a lot of data you will only get the first part. Instead you have to do it on the end event.

const { spawn } = require('child_process');
const pythonDir = (__dirname + "/../pythonCode/"); // Path of python script folder
const python = pythonDir + "pythonEnv/bin/python"; // Path of the Python interpreter

/** remove warning that you don't care about */
function cleanWarning(error) {
    return error.replace(/Detector is not able to detect the language reliably.\n/g,"");
}

function callPython(scriptName, args) {
    return new Promise(function(success, reject) {
        const script = pythonDir + scriptName;
        const pyArgs = [script, JSON.stringify(args) ]
        const pyprog = spawn(python, pyArgs );
        let result = "";
        let resultError = "";
        pyprog.stdout.on('data', function(data) {
            result += data.toString();
        });

        pyprog.stderr.on('data', (data) => {
            resultError += cleanWarning(data.toString());
        });

        pyprog.stdout.on("end", function(){
            if(resultError == "") {
                success(JSON.parse(result));
            }else{
                console.error(`Python error, you can reproduce the error with: \n${python} ${script} ${pyArgs.join(" ")}`);
                const error = new Error(resultError);
                console.error(error);
                reject(resultError);
            }
        })
   });
}
module.exports.callPython = callPython;

Call:

const pythonCaller = require("../core/pythonCaller");
const result = await pythonCaller.callPython("preprocessorSentiment.py", {"thekeyYouwant": value});

python:

try:
    argu = json.loads(sys.argv[1])
except:
    raise Exception("error while loading argument")

Many of the examples are years out of date and involve complex setup. You can give JSPyBridge/pythonia a try (full disclosure: I'm the author). It's vanilla JS that lets you operate on foreign Python objects as if they existed in JS. In fact, it does interoperability so Python code can in return call JS through callbacks and passed functions.

numpy + matplotlib example, with the ES6 import system:

import { py, python } from 'pythonia'
const np = await python('numpy')
const plot = await python('matplotlib.pyplot')

// Fixing random state for reproducibility
await np.random.seed(19680801)
const [mu, sigma] = [100, 15]
// Inline expression evaluation for operator overloading
const x = await py`${mu} + ${sigma} * ${np.random.randn(10000)}`

// the histogram of the data
const [n, bins, patches] = await plot.hist$(x, 50, { density: true, facecolor: 'g', alpha: 0.75 })
console.log('Distribution', await n) // Always await for all Python access
await plot.show()
python.exit()

Through CommonJS (without top level await):

const { py, python } = require('pythonia')
async function main() {
  const np = await python('numpy')
  const plot = await python('matplotlib.pyplot')
  ...
  // the rest of the code
}
main().then(() => python.exit()) // If you don't call this, the process won't quit by itself.